Experience & Education
school
Education
M.Sc. Bioinformatics
account_balanceManipal School of Life Sciences, MAHE, Karnataka
CGPA: 9.31Project: Development of a Biophysics-Informed AI Tool for Predicting Stability Effects of Mutations in Membrane Proteins
B.Sc. Biotechnology
account_balanceFergusson College, Pune, Maharashtra
CGPA: 8.35
science
Research Experience
Membrane Protein Stability Prediction (Final Project)
domainManipal School of Life Sciences | Dr. Budheswar Dehury
- Curated an experimental stability dataset for membrane proteins and engineered a structural feature matrix (H5py) combining sequence and structural descriptors extracted via MDAnalysis, RING4, and FreeSASA.
- Fine-tuned and trained the ESM2 protein language model (PyTorch) as the sequence-based backbone of a proof-of-concept framework for predicting mutation induced ΔΔG in membrane proteins.
- Established feasibility of the framework as a foundation for further PhD stage work incorporating graph neural networks (GNNs) and an expanded structural feature set.
SLC45A4 Structural & Simulation Study (Mini Project)
business_centerManipal School of Life Sciences | Dr. Budheswar Dehury
- Investigated the binding of SLC45A4, a pain associated neuronal polyamine transporter, with its three known substrates to identify residues critical for substrate recognition and to characterize the binding mechanism.
- Performed molecular dynamics simulation analysis, formal data analysis, and visualization, and jointly led the manuscript as first author.
Immunomodulatory Effects Study
business_centerFergusson College | Dr. Divya N Prakash
- Studied the immunomodulatory effect of prebiotic and probiotic conditioned media on human macrophages in vitro during the final year of B.Sc.